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Thyroid Hormone Synthesis

The first step in the synthesis of thyroid hormones is the organification of iodine.  Iodide is taken up, converted to iodine, and then condensed onto tyrosine residues which reside along the polypeptide backbone of a protein molecule called thyroglobulin.  This reaction results in either a mono-iodinated tyrosine (MIT) or di-iodinated …

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