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Chapter 3 – Principles of Neoplasia

3-2a Carcinogenesis Part 1

CARCINOGENESIS I. BASIC PRINCIPLES A. Cancer formation is initiated by damage to DNA of stem cells. The damage overcomes DNA repair mechanisms, but is not lethal. i. Carcinogens are agents that damage DNA, increasing the risk for cancer. Important carcinogens include chemicals, oncogenic viruses, and radial ion (Table 3.2). B. …

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3-3b Carcinogenesis Part 2

CARCINOGENESIS I. BASIC PRINCIPLES A. Cancer formation is initiated by damage to DNA of stem cells. The damage overcomes DNA repair mechanisms, but is not lethal. i. Carcinogens are agents that damage DNA, increasing the risk for cancer. Important carcinogens include chemicals, oncogenic viruses, and radial ion (Table 3.2). B. …

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3-4c Carcinogenesis part 3

CARCINOGENESIS I. BASIC PRINCIPLES A. Cancer formation is initiated by damage to DNA of stem cells. The damage overcomes DNA repair mechanisms, but is not lethal. i. Carcinogens are agents that damage DNA, increasing the risk for cancer. Important carcinogens include chemicals, oncogenic viruses, and radial ion (Table 3.2). B. …

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3-6 Clinical Characteristics

NEOPLASIA I. BASIC PRINCIPLES A. Neoplasia is new I issue growth that is unregulated, irreversible, and monoclonal; these features distinguish it from hyperplasia and repair. B. Monoclonal means that the neoplastic cells are derived from a single mother cell. C. Qonality can be determined by glucose-6-phosphate dehydrogenase (G6PD) enzyme iso …

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